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Creators/Authors contains: "Traficante, Emily F"

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  1. ; ; ; (, Synthesis)
    Since the first reports of their isolation, the meroterpenoids cochlearol A and B have attracted interest from the synthetic community for their unique structural features. This review describes the attempted and successful total syntheses of these natural products and provides a summary of the strategies developed in the years since their isolation. 
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  2. ; ; ; ; (, Angewandte Chemie International Edition)
    Abstract A 14‐step synthesis of (+)‐cochlearol B is reported. This renoprotective meroterpenoid features a unique core structure containing a densely substituted cyclobutane ring with three stereocenters. Our strategy employed an organocatalytic Kabbe condensation in route to the key chromenyl triflate. A subsequent Catellani reaction incorporated the remaining carbon atoms featured in the skeleton of cochlearol B. An ensuing visible‐light‐mediated [2+2] photocycloaddition closed the cyclobutane and formed the central bicyclo[3.2.0]heptane core. Notably, careful design and tuning of the Catellani and photocycloaddition reactions proved crucial in overcoming undesired reactivity, including cyclopropanation reactions and [4+2] cycloadditions. 
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